Disruptive 3D in vitro models for respiratory disease investigation: A state-of-the-art approach focused on SARS-CoV-2 infection

Maria Luiza Seixas 1, Cynthia Silva Bartolomeo 1 2, Robertha Lemes 3 4, Tiago Nicoliche 1, Liria Hiromi Okuda 5, Leonardo Martins 6, Rodrigo Ureshino 3 4 7, Carla Maximo Prado 2, Tácia Tavares Aquinas Liguori 8, Gabriel Romero Liguori 8, Roberta Sessa Stilhano 1 7

1 Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
2 Department of Biosciences, Federal University of São Paulo, Santos, Brazil.
3 Department of Biological Sciences, Federal University of São Paulo, Diadema, Brazil.
4 Laboratory of Molecular and Translational Endocrinology, Federal University of São Paulo, São Paulo, SP, Brazil.
5 Biological Institute, Agriculture and Supply Department, São Paulo, SP, Brazil.
6 Division of Medical Sciences, Laboratory of Transcriptional Regulation, Institute of Medical Biology of Polish Academy of Sciences (IMB-PAN), Poland.
7 Post-graduation Program in Chemistry-Biology, Federal University of São Paulo, Diadema, Brazil.
8 TissueLabs Sagl, Manno, Switzerland.